Water → 2-phenyl-2,3-dihydrophthalazine-1,4-dione

HRID 1723323Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1723323
[C:1]1(=[O:11])[O:6][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[C:12]1([NH:18][NH2:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C([O-])(=O)C.[Na+].O>C(O)(=O)C>[C:12]1([N:18]2[NH:19][C:1](=[O:11])[C:2]3[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:4]2=[O:6])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 6811Phthalic AnhydrideHCID 7516PhenylhydrazineHCID 517045Sodium Acetate

Produkt 1

HCID 2257382-phenyl-2,3-dihydrophthalazine-1,4-dioneAusbeute 58 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of phthalic anhydride (0.02 mol) and phenyl hydrazine (0.04 mol) in 95 percent acetic acid (70 ml.) was heated to reflux for 24 hours in the presence of a catalytic amount of sodium acetate (0.4 g). Water was added to the mixture and the precipitate collected. The precipitate was washed with water, agitated with 2 percent aqueous solution of sodium hydroxide and filtered. The filtrate was acidified with concentrated hydrogen chloride. The precipitate was collected and recrystallized from ethyl acetate to produce the product, 2-phenyl-2,3-dihydrophthalazine-1,4-dione.

Aufarbeitung

  1. temperaturewas heated
  2. customthe precipitate collected
  3. washThe precipitate was washed with water
  4. filtrationfiltered
  5. customThe precipitate was collected
  6. customrecrystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-20347d331fd240689de4d23cb62d4932
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04861778

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