Acetic Acid → Ziprasidone Hydrochloride

HRID 1724634

Reaktionsgleichung

Reaktionsgleichung von HRID 1724634
[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]4[CH:19]=[C:20]5[CH2:28][C:26](=[O:27])[NH:25][C:21]5=[CH:22][C:23]=4[Cl:24])[CH2:12][CH2:11]3)[C:5]=2[CH:6]=1.C(O)(=O)C.[ClH:33].O>C(O)(C)C>[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][C:18]4[CH:19]=[C:20]5[CH2:28][C:26](=[O:27])[NH:25][C:21]5=[CH:22][C:23]=4[Cl:24])[CH2:14][CH2:15]3)[C:5]=2[CH:6]=1.[ClH:33]

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 962WaterHCID 60854Ziprasidone

Produkt 1

HCID 219099Ziprasidone Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
47.5 °C

Versuchsvorschrift

Ziprasidone (5 g) and 50 mL of acetic acid were placed into a round bottom flask and heated to 45-50° C. Added was 25 mL of aqueous hydrochloric acid slowly to the mixture over 20 min. Then the reaction mixture was refluxed. Water (10 mL) was added, followed by addition of 50 mL of Isopropanol. The reaction mass was cooled to 50° C. and distilled off the solvent completely under vacuum. The material formed was scratched from the flask.

Aufarbeitung

  1. additionAdded
  2. customover 20 min
  3. temperatureThen the reaction mixture was refluxed
  4. temperatureThe reaction mass was cooled to 50° C.
  5. distillationdistilled off the solvent completely under vacuum
  6. customThe material formed

Quellen und Nachweise

ORD-Eintrag
ord-9e5bbee97d30450b80ddca42bd2496c4
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07488729B2

Verknüpfte Notizen

Wird geladen…