Acetic Anhydride → N-(3-Chloro-4-fluorophenyl)acetamide
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].[C:10](OC(=O)C)(=[O:12])[CH3:11]>O>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][C:8]=1[F:9]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To 3-chloro-4-fluoroaniline (100 g) was slowly added acetic anhydride (200 ml). After allowed to stand for 30 minutes, the reaction mixture was poured into water (1 litter). The resulting precipitate was collected by filtration and recrystallized from aqueous ethanol to give the title compound (119.4 g), mp 118°-119° C.
Aufarbeitung
- filtrationThe resulting precipitate was collected by filtration
- customrecrystallized from aqueous ethanol
Quellen und Nachweise
- ORD-Eintrag
- ord-5e5001753cee4cfdbeb924443d6973e6
- Quelldatensatz
- uspto-grants-1989_05
- Patentnummer
- US04826982
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