Formic Acid → methyl N-formyl-N-(1,2,3,4,4a,9a-hexahydro-9H-fluoren-9-yl)glycine

HRID 1762041Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1762041
[CH3:1][N:2]([CH:7]1[CH:19]2[CH:14]([CH2:15][CH2:16][CH2:17][CH2:18]2)[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:3][C:4](O)=O.[CH:20]([OH:22])=[O:21].C(OC(=O)C)(=[O:25])C>O>[CH3:4][CH:3]([C:20]([OH:22])=[O:21])[N:2]([CH:1]=[O:25])[CH:7]1[CH:19]2[CH:14]([CH2:15][CH2:16][CH2:17][CH2:18]2)[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2

Komponenten

5

Edukt 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 70360266methyl N-(1,2,3,4,4a,9a-hexahydro-9H-fluoren-9-yl)glycine

Produkt 1

HCID 86743034methyl N-formyl-N-(1,2,3,4,4a,9a-hexahydro-9H-fluoren-9-yl)glycineAusbeute 86,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 16.6 parts of methyl N-(1,2,3,4,4a,9a-hexahydro-9H-fluoren-9-yl)glycine, 44 parts of formic acid and 11.9 parts of acetic acid anhydride was stirred overnight at room temperature. The reaction mixture was poured into water and the product was extracted with trichloromethane. The extract was dried, filtered and evaporated, yielding 15.9 parts (86.4%) of methyl N-formyl-N-(1,2,3,4,4a,9a-hexahydro-9H-fluoren-9-yl)glycine as a residue (int. 2).

Aufarbeitung

  1. extractionthe product was extracted with trichloromethane
  2. customThe extract was dried
  3. filtrationfiltered
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-75758b91c41a42b78088aa77e9a38eda
Quelldatensatz
uspto-grants-1989_05
Patentnummer
US04830664

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