Bromine → 5-(Benzyloxy)-3-bromopyridin-2-amine

HRID 1806091Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1806091
Cl.[CH2:2]([O:9][C:10]1[CH:11]=[CH:12][C:13]([NH2:16])=[N:14][CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C([O-])(=O)C.[Na+].[Br:22]Br>C(O)(=O)C>[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([Br:22])[C:13]([NH2:16])=[N:14][CH:15]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Komponenten

5

Edukt 3

HCID 24408BromineHCID 517045Sodium AcetateHCID 669951705-Benzyloxy-pyridin-2-ylamine hydrochloride

Produkt 1

HCID 582090735-(Benzyloxy)-3-bromopyridin-2-amineAusbeute 17 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

5-(Benzyloxy)pyridin-2-amine hydrochloride (52.3 g, 221 mmol) and sodium acetate (45.3 g, 552 mmol) were dissolved in acetic acid (300 mL). Bromine (11.3 mL, 221 mmol) was added slowly and stirred at ambient temperature for 18 hours. After an aqueous workup, the material was purified over silica gel to give the title compound (10.5 g, 17.0% yield).

Aufarbeitung

  1. customAfter an aqueous workup, the material was purified over silica gel

Quellen und Nachweise

ORD-Eintrag
ord-6750e4ac7a1a448796288b9d4020c74f
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354540B2

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