Cyanogen Bromide → HCID 178508200, Verbindung

HRID 1845110Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1845110
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([NH2:11])[CH:5]=1)([O-:3])=[O:2].Br[C:13]#[N:14]>C(O)C.O>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]2[NH:10][C:13]([NH2:14])=[N:11][C:6]=2[CH:5]=1)([O-:3])=[O:2]

Komponenten

5

Edukt 2

HCID 10476Cyanogen BromideHCID 51117914-Nitro-1,2-phenylenediamine

Produkt 1

HCID 178508200HCID 178508200, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

7.6 g (50 mmol) of 4-nitro-ortho-phenylenediamine was dissolved were dissolved in 100 mL of ethanol and 20 mL of H2O. 7.9 g (75 mmol) of BrCN was added in one portion to this stirring solution, and the resulting mixture was heated under reflux for 1.0 h. The reaction mixture was cooled to room temperature, concentrated to 20 mL then neutralized with saturated NaHCO3 solution to ˜pH 8, and resulting solid 5-nitro-1H-benzoimidazol-2-ylamine collected via filtration was used directly in the next step without further purification.

Aufarbeitung

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 1.0 h
  3. concentrationconcentrated to 20 mL

Quellen und Nachweise

ORD-Eintrag
ord-ab04dacf0fd54cb39df8a5c16eb4c03b
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946259B2

Notizen zur Reaktion

Wird geladen…