Acetic Acid → (1,1'-Biphenyl)-4-butanoic acid, gamma-hydroxy-

HRID 1856512

Reaktionsgleichung

Reaktionsgleichung von HRID 1856512
[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][C:4]([C:7]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8])=[CH:3][CH:2]=1.[OH-].[Na+].[BH4-].[Na+].C(O)(=O)C>O>[OH:8][CH:7]([C:4]1[CH:5]=[CH:6][C:1]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:2][CH:3]=1)[CH2:9][CH2:10][C:11]([OH:13])=[O:12]

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 3335FenbufenHCID 14798Sodium HydroxideHCID 4311764Sodium borohydride

Produkt 1

HCID 16072199(1,1'-Biphenyl)-4-butanoic acid, gamma-hydroxy-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A 25.4 g. portion of 3-(4-biphenylylcarbonyl)propionic acid is dissolved in 2 liters of water made alkaline with sodium hydroxide. A 37.8 g. portion of sodium borohydride is added and the mixture is stirred for 2 hours. The suspension is then slowly poured into 100 ml. of glacial acetic acid. The mixture is cooled and the resulting solid is filtered, washed with water and dried giving the desired product, m.p. 139°-140° C.

Aufarbeitung

  1. additionThe suspension is then slowly poured into 100 ml
  2. temperatureThe mixture is cooled
  3. filtrationthe resulting solid is filtered
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-683b6ab37ab6474ab8171af01f918ae9
Quelldatensatz
uspto-grants-1980_08
Patentnummer
US04219668

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