Water → HCID 59620340, Verbindung

HRID 1887744Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1887744
Br[C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([N+:12]([O-])=O)[CH:11]=1)[NH:8][C:7](=[O:15])[CH:6]([NH:16][C:17](=[O:19])[CH3:18])[CH2:5]2.C([O-])=O.[NH4+].O>C(O)C.[Pd]>[NH2:12][C:10]1[CH:11]=[CH:2][CH:3]=[C:4]2[C:9]=1[NH:8][C:7](=[O:15])[CH:6]([NH:16][C:17](=[O:19])[CH3:18])[CH2:5]2

Komponenten

6

Edukt 3

HCID 962WaterHCID 2723923Ammonium formateHCID 59620398HCID 59620398, Verbindung

Produkt 1

HCID 59620340HCID 59620340, VerbindungAusbeute 84,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

N-(6-Bromo-8-nitro-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)acetamide (15 g) was suspended in ethanol (150 mL), and ammonium formate (28.8 g) and 10% Pd—C (water content: 53%) (1.5 g) were added thereto. The mixture was heated at 80° C. while being stirred for 30 minutes, and water (150 mL) and ethanol (150 mL) were added thereto, followed by filtration while being heated. The filtrate was concentrated under reduced pressure, and the formed precipitates were recovered through filtration. The thus-obtained solid was washed with ethanol and diisopropyl ether, followed by drying, whereby the title compound (8.5 g) was yielded.

Aufarbeitung

  1. filtrationfollowed by filtration
  2. temperaturewhile being heated
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customthe formed precipitates
  5. filtrationwere recovered through filtration
  6. washThe thus-obtained solid was washed with ethanol and diisopropyl ether
  7. customby drying

Quellen und Nachweise

ORD-Eintrag
ord-d1d3c7e6655740a5bd30cf0e49dcf14e
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501772B2

Notizen zur Reaktion

Wird geladen…