Thiophosgene → 2-Chloro-4-methylphenyl isothiocyanate

HRID 1898301

Reaktionsgleichung

[Cl:1][C:2]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:10](Cl)(Cl)=[S:11].C(N(C(C)C)C(C)C)C>>[Cl:1][C:2]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:3]=1[N:4]=[C:10]=[S:11]

Komponenten

Edukt 3

HCID 10040Thiophosgene

HCID 120072-Chloro-p-toluidine

HCID 81531Diisopropylethylamine

Produkt 1

HCID 1435292-Chloro-4-methylphenyl isothiocyanateAusbeute 58,3 %

Versuchsvorschrift

The title compound was prepared following the procedure described for intermediate-2 using 2-chloro-4-methyl aniline (2.0 g, 14.00 mmol), thiophosgene (1.62 g, 14.00 mmol) and N-ethyl di-isopropyl amine (3.63 g, 28.00 mmol) to afford 1.5 g of the desired product.

Aufarbeitung

customThe title compound was prepared

Quellen und Nachweise

ORD-Eintrag: ord-3b59b75f740b42dfa65e357b2132c9af
Quelldatensatz: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08519149B2

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