5'-Chloro-4'-(2-(2,4-di-tert-pentylphenoxy)butyrylamino)-2'-hydroxybenzanilide → HCID 20036204, Verbindung

HRID 1904888

Reaktionsgleichung

Reaktionsgleichung von HRID 1904888
[C:1]([NH:9][C:10]1[CH:15]=[C:14]([Cl:16])[C:13]([NH:17][C:18](=[O:39])[CH:19]([O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]([CH2:32][CH3:33])([CH3:31])[CH3:30])=[CH:25][C:24]=2[C:34]([CH2:37][CH3:38])([CH3:36])[CH3:35])[CH2:20][CH3:21])=[CH:12][C:11]=1[OH:40])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:41]([O-:43])=[O:42].[Na+]>C(O)(=O)C.CN(C)C=O.O>[N+:41]([C:12]1[C:13]([NH:17][C:18](=[O:39])[CH:19]([O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]([CH2:32][CH3:33])([CH3:31])[CH3:30])=[CH:25][C:24]=2[C:34]([CH2:37][CH3:38])([CH3:36])[CH3:35])[CH2:20][CH3:21])=[C:14]([Cl:16])[CH:15]=[C:10]([NH:9][C:1](=[O:8])[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:11]=1[OH:40])([O-:43])=[O:42]

Komponenten

6

Edukt 2

HCID 5711085'-Chloro-4'-(2-(2,4-di-tert-pentylphenoxy)butyrylamino)-2'-hydroxybenzanilideHCID 23668193Sodium Nitrite

Produkt 1

HCID 20036204HCID 20036204, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

In 100 ml of acetic acid and 100 ml of dimethylformamide was dissolved 20 g (35×10-3 mole) of 2-benzamido-4-chloro-5-{2-(2,4-di-t-amylphenoxy)butanamido}phenol. To the solution was added dropwise slowly a solution of 2.7 g of sodium nitrite dissolved in 5 ml of a distilled water at room temperature, and then the mixture was stirred for 2 hours. The reaction mixture was poured into ice-cold water, and precipitated yellow solids were collected by filtration and washed with water. Yield: 21 g.

Aufarbeitung

  1. additionThe reaction mixture was poured into ice-cold water
  2. customprecipitated yellow solids
  3. filtrationwere collected by filtration
  4. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-0714156ea3fd4d35a1d4686d5fbcab5d
Quelldatensatz
uspto-grants-1989_06
Patentnummer
US04840883

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