Cyanogen Bromide → HCID 178508200, Verbindung

HRID 1910272Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1910272
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([NH2:11])[CH:5]=1)([O-:3])=[O:2].Br[C:13]#[N:14]>C(O)C.O>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]2[NH:10][C:13]([NH2:14])=[N:11][C:6]=2[CH:5]=1)([O-:3])=[O:2]

Komponenten

5

Edukt 2

HCID 10476Cyanogen BromideHCID 51117914-Nitro-1,2-phenylenediamine

Produkt 1

HCID 178508200HCID 178508200, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

7.6 g (50 mmol) of 4-nitro-ortho-phenylenediamine was dissolved were dissolved in 100 mL of ethanol and 20 mL of H2O. 7.9 g (75 mmol) of BrCN was added in one portion to this stirring solution, and the resulting mixture was heated under reflux for 1.0 h. The reaction mixture was cooled to room temperature, concentrated to 20 mL then neutralized with saturated NaHCO3 solution to pH 8, and resulting solid 5-nitro-1H-benzoimidazol-2-ylamine collected via filtration was used directly in the next step without further purification.

Aufarbeitung

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 1.0 h
  3. concentrationconcentrated to 20 mL

Quellen und Nachweise

ORD-Eintrag
ord-3ea16703b6f340cea4d921082031c3ec
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08598353B2

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