Hydrochloric Acid → HCID 89077752, Verbindung

HRID 1946212Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1946212
[CH3:1][C:2]1([CH3:28])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([O-:13])=O)[CH:9]=2)[N+:4]2[CH:14]=[CH:15][C:16]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:20]([CH3:27])[CH:19]=3)=[CH:17][C:3]1=2.[ClH:29].[C:30]([N:37]1[CH:41]=[CH:40]N=[CH:38]1)(N1C=CN=C1)=O.Cl.Cl.[NH2:44][CH2:45][CH2:46][S:47][S:48][CH2:49][CH2:50][NH2:51]>CN1CCCC1=O.O1CCOCC1.C(OCC)C.C(N(C(C)C)CC)(C)C.CC(C)=O>[Cl-:29].[Cl-:29].[S:47]([CH2:46][CH2:45][NH:44][C:11]([C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[N+:4]1[CH:14]=[CH:15][C:16]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:20]([CH3:27])[CH:19]=3)=[CH:17][C:3]=1[C:2]2([CH3:1])[CH3:28])=[O:13])[S:48][CH2:49][CH2:50][NH:51][C:11]([C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[N+:4]1[CH:14]=[CH:15][C:16]([C:40]3[C:25]4[C:38](=[CH:23][CH:22]=[CH:21][CH:26]=4)[N:37]([CH3:30])[CH:41]=3)=[CH:17][C:3]=1[C:2]2([CH3:28])[CH3:1])=[O:13]

Komponenten

10

Edukt 4

HCID 313Hydrochloric AcidHCID 5941Cystamine DihydrochlorideHCID 682631,1'-CarbonyldiimidazoleHCID 68743932HCID 68743932, Verbindung

Produkt 1

HCID 89077752HCID 89077752, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 5

HCID 180AcetoneLösungsmittelHCID 3283Diethyl EtherLösungsmittelHCID 13387N-methyl-2-pyrrolidoneLösungsmittelHCID 312751,4-DioxaneLösungsmittelHCID 81531DiisopropylethylamineLösungsmittel

Versuchsvorschrift

10,10-dimethyl-8-(1-methyl-1H-indol-3-yl)-10H-pyrido-[1,2-a]indolium-2-carboxylate 0.37 g was solubilized in 5 mL N-methylpyrrolidinone (NMP), a solution of HCl in dry dioxane and diethyl ether (1 mL; 1N; 1:3) was added and 1,1′-carbonyldiimidazole (320 mg) was progressively added. After 3 h, 200 mg of cystamine dihyrochloride in mL diisopropylethylamine (DIPEA) were added to the mixture. After 24 h, the reaction mixture was poured in 100 mL acetone. The resulting solid was filtered, washed with acetone and dried under vacuum (340 mg, yellow powder). Analyses were in accordance with the expected structure.

Aufarbeitung

  1. waitAfter 24 h
  2. filtrationThe resulting solid was filtered
  3. washwashed with acetone
  4. customdried under vacuum (340 mg, yellow powder)

Quellen und Nachweise

ORD-Eintrag
ord-38778b693abf47bc90b7d54082ae4183
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08398722B2

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