Water → 5-(Benzyloxy)pyridine-2-carboxylic acid

HRID 1950009Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1950009
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]=[O:16])=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.S(=O)(=O)([OH:20])N.Cl([O-])=O.[Na+]>CC(C)=O>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([OH:20])=[O:16])=[N:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 5987Sulfamic AcidHCID 123972545-(Benzyloxy)pyridine-2-carbaldehydeHCID 23668197Sodium Chlorite

Produkt 1

HCID 183793525-(Benzyloxy)pyridine-2-carboxylic acidAusbeute 73,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a solution of 5-benzyloxypyridine-2-carbaldehyde (3.8 g) in acetone (50 ml) was added water (50 ml), sulfamic acid (2.4 g) and sodium chlorite (2.2 g) were sequentially added thereto on an ice bath, and the solution was stirred for 6 hours at room temperature. The solid that was precipitated was filtered and rinsed with water to provide the title compound (3.0 g).

Aufarbeitung

  1. additionwere sequentially added
  2. customThe solid that was precipitated
  3. filtrationwas filtered
  4. washrinsed with water

Quellen und Nachweise

ORD-Eintrag
ord-89d035fca62745bca76173e20e6a7228
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08399520B2

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