Bromine → 4-bromo-1-butyl-5-methyl-1H-pyrazole-3-carbonitrile

HRID 1984333

Reaktionsgleichung

Reaktionsgleichung von HRID 1984333
[CH2:1]([N:5]1[C:9]([CH3:10])=[CH:8][C:7]([C:11]#[N:12])=[N:6]1)[CH2:2][CH2:3][CH3:4].C([O-])(=O)C.[K+].[Br:18]Br>C(O)(=O)C>[Br:18][C:8]1[C:7]([C:11]#[N:12])=[N:6][N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[C:9]=1[CH3:10]

Komponenten

5

Edukt 3

HCID 24408BromineHCID 517044Potassium AcetateHCID 669586171-butyl-5-methyl-1H-pyrazole-3-carbonitrile

Produkt 1

HCID 669586224-bromo-1-butyl-5-methyl-1H-pyrazole-3-carbonitrileAusbeute 101,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

1-Butyl-5-methyl-1H-pyrazole-3-carbonitrile (6.58 g, 38 mmol) was treated with potassium acetate (57.2 mmol) and bromine (41.9 mmol) in acetic acid (50 mL) according to a modification of the method described in Part F of Examples 1-4. The reaction provided 9.3 g of 4-bromo-1-butyl-5-methyl-1H-pyrazole-3-carbonitrile as a colorless oil that crystallized upon standing. The crystals were used without purification.

Quellen und Nachweise

ORD-Eintrag
ord-230fb44ff9e741f4892329724ecb37bb
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07544697B2

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