Hydrazine hydrate (1:1) → 1H-pyrrole-2-carbohydrazonamide

HRID 2048131Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2048131
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]#[N:7].C[O-].[Na+].O.[NH2:12][NH2:13]>C(O)C.O>[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[N:12][NH2:13])[NH2:7]

Komponenten

6

Edukt 3

HCID 24654Hydrazine hydrate (1:1)HCID 138277Pyrrole-2-carbonitrileHCID 10942334Sodium Methoxide

Produkt 1

HCID 1363872481H-pyrrole-2-carbohydrazonamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 1H-pyrrole-2-carbonitrile 10 g (108 mM) and sodium methoxide (1 eq) in ethanol (20 ml) and stirred for 10 min. Hydrazine hydrate (3 eq.) is then added and resulting reaction mixture is stirred at room temperature for 18 hrs. Reaction mass is then diluted with water, extracted with ethyl acetate, dried over anhydrous sodium sulphate and concentrated under vacuum to yield desired compound.

Aufarbeitung

  1. customresulting
  2. customreaction mixture
  3. customReaction mass
  4. extractionextracted with ethyl acetate
  5. dry with materialdried over anhydrous sodium sulphate
  6. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b2f4fdbed86e461184fdb9e306592e34
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08592591B2

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