Acetic Acid → 2,6-Diisopropylphenyl acetate

HRID 2065981

Reaktionsgleichung

FC(F)(F)C(OC(=O)C(F)(F)F)=O.[C:14]([OH:17])(=[O:16])[CH3:15].[CH:18]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]([CH3:29])[CH3:28])[C:22]=1O)([CH3:20])[CH3:19]>O>[C:14]([O:17][C:22]1[C:21]([CH:18]([CH3:19])[CH3:20])=[CH:26][CH:25]=[CH:24][C:23]=1[CH:27]([CH3:29])[CH3:28])(=[O:16])[CH3:15]

Komponenten

Reaktionsbedingungen

Temperatur: 0 °C

Versuchsvorschrift

3.45 g (16.4 mmol) of trifluoroacetic anhydride is added to 0.83 ml (14.6 mmol) of acetic acid at 0° C. while leaving the mixture to return to ambient temperature over 2 hours. The mixture is then cooled down to 0° C. and 1.95 g (11.0 mmol) of 2,6-diisopropylphenol is added dropwise. The reaction medium is maintained under stirring for 12 hours before being poured into ice-cooled water. After extraction with dichloromethane, the organic phase is washed with sodium chloride in a saturated aqueous solution before being dried over magnesium sulphate, filtered and concentrated under vacuum. A colourless oil is obtained with a yield of 86%. This product is sufficiently pure to be used directly in the following stage.

Aufarbeitung

customwhile leaving the mixture
temperatureThe reaction medium is maintained
additionbefore being poured into ice-
extractionAfter extraction with dichloromethane
washthe organic phase is washed with sodium chloride in a saturated aqueous solution
dry with materialbefore being dried over magnesium sulphate
filtrationfiltered
concentrationconcentrated under vacuum
customA colourless oil is obtained with a yield of 86%

Quellen und Nachweise

ORD-Eintrag: ord-c9ac66a01b0045e497c52de8b4afe73e
Quelldatensatz: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08288560B2

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