Cyclopentanone → 1-(Diethylamino)cyclopentanecarbonitrile

HRID 20792

Reaktionsgleichung

Reaktionsgleichung von HRID 20792
Cl.[CH2:2]([NH:4][CH2:5][CH3:6])[CH3:3].[C:7]1(=O)[CH2:11][CH2:10][CH2:9][CH2:8]1.[C-]#N.[K+].[CH3:16][N:17](C)C1(C#N)CCCC1>O>[CH2:2]([N:4]([CH2:5][CH3:6])[C:7]1([C:16]#[N:17])[CH2:11][CH2:10][CH2:9][CH2:8]1)[CH3:3]

Komponenten

6

Edukt 4

HCID 8452CyclopentanoneHCID 9032Potassium CyanideHCID 10197650Diethylammonium chlorideHCID 107730491-(Dimethylamino)cyclopentanecarbonitrile

Produkt 1

HCID 242767611-(Diethylamino)cyclopentanecarbonitrileAusbeute 62 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The title compound (2.06 g, 62%) was prepared from diethylamine hydrochloride (2.14 g, 20 mmol), cyclopentanone (1.68 g, 20 mmol) and potassium cyanide (1.30 g, 20 mmol) in water (10 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.11 (6H, t, J=7 Hz), 1.78-1.88 (6H, m), 2.22 (2H, m), 2.71 (4H, q, J=7 Hz).

Quellen und Nachweise

ORD-Eintrag
ord-10ca5a0bc6414f21970b59dd43514c14
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745642B2

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