Water → 3,5-dimethyl-N-phenyl-1H-pyrazole-4-carboxamide

HRID 2163520Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2163520
[C:1]([CH:4]([C:14](=O)[CH3:15])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6])(=O)[CH3:2].O.[NH2:18][NH2:19].O>C(O)(=O)C>[CH3:2][C:1]1[C:4]([C:5]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:6])=[C:14]([CH3:15])[NH:19][N:18]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 22033802HCID 22033802, Verbindung

Produkt 1

HCID 107038853,5-dimethyl-N-phenyl-1H-pyrazole-4-carboxamideAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

The foregoing diacetyl acetanilide (2.2 g) in glacial acetic acid (30 ml) was treated with hydrazine hydrate (1.5 g) and the mixture boiled under reflux for 30 min. The mixture was then poured into water and the product collected and crystallised from ethanol. 3,5-dimethyl-N-phenyl-4-pyrazolecarboxamide (1.9 g, 86%) was obtained as colourless plates, m.p. 244-5° C (Found: C, 66.8 H, 6.0 N, 19.3 C12H13N3O requires C, 66.9; H, 6.1; N, 19.5%).

Aufarbeitung

  1. temperatureunder reflux for 30 min
  2. customthe product collected
  3. customcrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-fafb41a2053543a0be3cc30d3ef182a7
Quelldatensatz
uspto-grants-1979_01
Patentnummer
US04134987

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