Acetic Acid → N-tert-Butoxycarbonyl-trans-4-(N,N-Dimethylglycylamino)-L-Proline

HRID 2185421Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2185421
O.[OH-].[Li+].C[O:5][C:6](=[O:26])[C@@H:7]1[CH2:11][C@@H:10]([NH:12][C:13](=[O:18])[CH2:14][N:15]([CH3:17])[CH3:16])[CH2:9][N:8]1[C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20].CO.C(O)(=O)C>O.O1CCCC1>[C:22]([O:21][C:19]([N:8]1[CH2:9][C@H:10]([NH:12][C:13](=[O:18])[CH2:14][N:15]([CH3:16])[CH3:17])[CH2:11][C@H:7]1[C:6]([OH:26])=[O:5])=[O:20])([CH3:25])([CH3:24])[CH3:23]

Komponenten

7

Edukt 4

HCID 176Acetic AcidHCID 887MethanolHCID 168937Lithium hydroxide, monohydrateHCID 21341540N-tert-Butoxycarbonyl-trans-4-(N,N-Dimethylglycylamino)-L-Proline Methyl Ester

Produkt 1

HCID 21341539N-tert-Butoxycarbonyl-trans-4-(N,N-Dimethylglycylamino)-L-Proline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of lithium hydroxide monohydrate (40 mg) in water (1 mL) was added to a solution of N-tert-butoxycarbonyl-trans-4-(N,N-dimethylglycylamino)-L-proline methyl ester (A, 264 mg) in tetrahydrofuran (3 mL)-methanol (1 mL) at 0° C. After stirring at room temperature for 4 hr, acetic acid (55 L) was added to the reaction mixture at 0° C. The resulting solution was evaporated in vacuo to afford the crude title compound, which is used in the subsequent step.

Aufarbeitung

  1. customThe resulting solution was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-543747a9b3074c3a9fc17da6471de2aa
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06399629B1

Notizen zur Reaktion

Wird geladen…