Reaktionsgleichung
[C:1](#[N:4])[CH:2]=[CH2:3].C1(P(C(C)(C)C)C(C)(C)C)C=CC=CC=1.[F:20][C:21]([F:34])([F:33])[C:22]1[CH:23]=[C:24](Cl)[CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1.C1(C(N)C2CCCCC2)CCCCC1>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.O.CC(N(C)C)=O>[F:20][C:21]([F:33])([F:34])[C:22]1[CH:23]=[C:24]([CH:25]=[C:26]([C:28]([F:29])([F:30])[F:31])[CH:27]=1)[CH:3]=[CH:2][C:1]#[N:4]Komponenten
8
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
0.382 g (7.2 mmol) of acrylonitrile, 38.7 mg (120 μmol) of NBu4Br, 6.7 mg (30 μmol) of palladium acetate and 26.7 mg (120 μmol) of phenyldi(t-butyl)phosphine are weighed into a Schlenk vessel. 1.49 g (6 mmol) of 3,5-bis(trifluoromethyl)chlorobenzene and 1.53 ml (7.2 mmol) of dicyclohexylmethylamine and also 3.5 ml of dimethylacetamide are then added. The Schlenk vessel is placed in a heating bath at 130° C. and the contents are stirred. After 4 hours, the contents are poured into 30 ml of water and the product is extracted by shaking with t-butyl methyl ether. After drying the organic phase over MgSO4, the solvent is removed under reduced pressure and the product is isolated. Orange oil, yield: 69%.
Aufarbeitung
- customThe Schlenk vessel is placed in a heating bath at 130° C.
- extractionthe product is extracted
- stirringby shaking with t-butyl methyl ether
- dry with materialAfter drying the organic phase over MgSO4
- customthe solvent is removed under reduced pressure
- customthe product is isolated
Quellen und Nachweise
- ORD-Eintrag
- ord-fb848583d510498d9da13547449a7f6e
- Quelldatensatz
- uspto-grants-2006_09
- Patentnummer
- US07102046B2
Verknüpfte Notizen
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