Sodium Carbonate → HCID 21956430, Verbindung

HRID 2213733Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2213733
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:15])=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]#[N:17].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:24]=[C:25]([O:29][CH3:30])[C:26]=1[O:27][CH3:28])[NH2:23].Cl.N1C=CC=CC=1.C(=O)([O-])[O-].[Na+].[Na+]>C(OCCO)C.O>[Cl:15][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:23][C:22]3[CH:24]=[C:25]([O:29][CH3:30])[C:26]([O:27][CH3:28])=[C:20]([O:19][CH3:18])[CH:21]=3)=[C:3]([C:16]#[N:17])[CH:4]=[N:5]2)=[CH:10][C:9]=1[N+:12]([O-:14])=[O:13]

Komponenten

7

Edukt 4

HCID 10340Sodium CarbonateHCID 322853,4,5-TrimethoxyanilineHCID 10176127Pyridinium chlorideHCID 219564524,7-Dichloro-6-nitroquinoline-3-carbonitrile

Produkt 1

HCID 21956430HCID 21956430, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8076Glycol monoethyl etherLösungsmittel

Versuchsvorschrift

A mixture of 500 mg (1.86 mmol) of 4,7-dichloro-6-nitro-3-quinolinecarbonitrile, 342.0 mg (1.86 mmol) of 3,4,5-trimethoxyaniline and 215.5 mg (1.86 mmol) of pyridine hydrochloride in 25 mL of 2-ethoxyethanol is heated at 100–110° C. for 1.5 hours. After cooling, the mire is diluted with water and neutralized with an aqueous solution of saturated sodium carbonate. The solid is collected by filtration and is washed with water. After drying in vacuo, this yields 621.0 mg (80.5%) of the product as a deep yellow solid.

Aufarbeitung

  1. temperatureis heated at 100–110° C. for 1.5 hours
  2. temperatureAfter cooling
  3. filtrationThe solid is collected by filtration
  4. washis washed with water
  5. customAfter drying in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2eed339c25f8416f9f378e93619eeaae
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07105531B2

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