Water → 4-Amino-3-bromo-5-(trifluoromethoxy)benzoic acid

HRID 2216768Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2216768
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:11][C:12]([F:15])([F:14])[F:13].[Br:16]Br.O>C(O)(=O)C>[NH2:1][C:2]1[C:3]([O:11][C:12]([F:13])([F:14])[F:15])=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:9][C:10]=1[Br:16]

Komponenten

5

Edukt 3

HCID 962WaterHCID 24408BromineHCID 27359514-amino-3-(trifluoromethoxy)benzoic Acid

Produkt 1

HCID 219424074-Amino-3-bromo-5-(trifluoromethoxy)benzoic acidAusbeute 57,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Versuchsvorschrift

To a solution of 4-amino-3-trifluoromethoxybenzoic acid (5 g, 22.6 mmoles) in acetic acid (50 mL), bromine (3.98 g, 24.9 mmoles) in acetic acid (10 mL) was added dropwise at room temperature. After the reaction mixture was kept stirring for one hour, water was added into the mixture. The solid was filtered and washed with water to give 4-amino-3-bromo-5-trifluoromethoxybenzoic acid (3.9 g, 54.9%).

Aufarbeitung

  1. filtrationThe solid was filtered
  2. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-4a116d547ab140c49ab55dfcb9149b51
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07112595B2

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