Bromine → 5-Bromo-3-fluoro-2-hydroxybenzoic acid

HRID 2234620Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2234620
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=[O:6])[C:3]=1[OH:11].[Br:12]Br>C(O)(=O)C.O>[Br:12][C:9]1[CH:10]=[C:2]([F:1])[C:3]([OH:11])=[C:4]([CH:8]=1)[C:5]([OH:7])=[O:6]

Komponenten

5

Edukt 2

HCID 24408BromineHCID 2687243-Fluoro-2-hydroxybenzoic acid

Produkt 1

HCID 117704165-Bromo-3-fluoro-2-hydroxybenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

5.00 g (32 mmol) of 3-fluorosalicylic acid was suspended in 50 ml of glacial acetic acid. 2.2 ml of bromine were added and the mixture was stirred at ambient temperature for 48 h. The resulting suspension was diluted with 500 ml of water and the precipitate filtered off and dried by suction to afford 9.394 g of 5-bromo-3-fluoro-2-hydroxybenzoic acid as an ivory solid.

Aufarbeitung

  1. filtrationthe precipitate filtered off
  2. customdried by suction

Quellen und Nachweise

ORD-Eintrag
ord-663bbcfc74cf4592b87e6a84e91cbbbc
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07709645B2

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