Reaktionsgleichung
Cl(O)(=O)(=O)=[O:2].[CH3:6][C:7]1[N:11]([CH2:12][CH:13]2[C:26](=[O:27])[C:17]3[C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=4[N:24]([CH3:25])[C:16]=3[CH2:15][CH2:14]2)[CH:10]=[CH:9][N:8]=1.[C:28]([OH:31])(=[O:30])[CH3:29]>>[CH3:25][N:24]1[C:16]2[CH2:15][CH2:14][CH:13]([CH2:12][N:11]3[CH:10]=[CH:9][N:8]=[C:7]3[CH3:6])[C:26](=[O:27])[C:17]=2[C:18]2[C:23]1=[CH:22][CH:21]=[CH:20][CH:19]=2.[C:28]([OH:31])(=[O:30])[CH:29]=[O:2]Komponenten
Versuchsvorschrift
A mixture containing 2.83 g (0.01 mole) of 3-hydroxy-methyl-9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one-3-glyoxylic acid lactone [compound of the formula (Ic)]and 1.64 g (0.02 mole) of 2-methylimidazole in 6.0 ml of sulfolane (tetramethylenesulfone) is heated in an oil bath of 150 to 160° C. for 15 minutes while stirring. After cooling down and diluting with 60 ml of acetone the precipitate is filtered off, washed with acetone and dried to give 0.95 g of the title compound, m.p.: 190°-200° C. (with decomposition). The active agent content of this product measured by titration with perchloric acid in glacial acetic acid was found to be 96%. In the combined filtrate of the reaction, ondansetron could be detected by thin layer chromatography. The most important characteristics of the title product are as follows:
Quellen und Nachweise
- ORD-Eintrag
- ord-e269cc799d2b4141a928ab8a459bf827
- Quelldatensatz
- uspto-grants-1995_12
- Patentnummer
- US05478949
Verknüpfte Notizen
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