Isopropyl iodide → 2-Cyano-2-(3,4-dimethoxyphenyl)-2-isopropylethyl-1,3-dioxolane

HRID 2276616Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2276616
C([Li])CCC.C(NC(C)C)(C)C.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:23](CCC2OCCO2)[C:24]#[N:25])[CH:18]=[CH:19][C:20]=1[O:21][CH3:22].BrCCC1OCCO1.C[O:42][C:43]1[CH:44]=[C:45]([CH2:51]C#N)[CH:46]=[CH:47][C:48]=1[O:49]C.IC(C)C.[NH4+].[Cl-]>C1COCC1.C(OCC)C>[C:24]([C:23]1([C:17]2[CH:18]=[CH:19][C:20]([O:21][CH3:22])=[C:15]([O:14][CH3:13])[CH:16]=2)[O:49][CH:48]([CH2:47][CH2:46][CH:45]([CH3:51])[CH3:44])[CH2:43][O:42]1)#[N:25]

Komponenten

10

Edukt 7

HCID 6362Isopropyl iodideHCID 7912Diisopropylamine2×HCID 25517Ammonium ChlorideHCID 667273,4-DimethoxybenzeneacetonitrileHCID 877762-(2-Bromoethyl)-1,3-dioxolaneHCID 426012402-(3,4-Dimethoxyphenyl)-4-(1,3)-dioxolan-2-yl-butyronitrileHCID 178418339Butyllithium2×

Produkt 1

HCID 671041742-Cyano-2-(3,4-dimethoxyphenyl)-2-isopropylethyl-1,3-dioxolaneAusbeute 49 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 8028TetrahydrofuranLösungsmittel2×

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

A solution of butyllithium (1.6 M solution in hexanes, 7.0 mL, 11.2 mmol) was added via syringe to a solution of diisopropylamine (1.5 mL, 10.61 mmol) in anhydrous THF (25 mL) at −78° C. And then a solution of 2-(3,4-dimethoxyphenyl)-4-(1,3)-dioxolan-2-yl-butyronitrile (18) (709 mg, 2.56 mmol) (previously prepared by reacting 2-(2-bromoethyl)-1,3-dioxolane with 2-(3,4-dimethoxyphenyl)-acetonitrile (14) in a solution diisopropylamine to which butyllithium was added) in THF (10 mL) was added via syringe. The mixture was stirred at −78° C. for five minutes and then 2-iodopropane (0.4 mL, 3.96 mmol) was added. The mixture was stirred at −78° C. for five hours and then at room temperature for 17.5 hours. Saturated NH4Cl solution (10 mL) was added to quench the reaction. Ethyl ether (60 mL) was added and the etheral solution was isolated. The aqueous solution was extracted with ether (2×20 mL). After washing with brine, drying with sodium sulfate, the solvent was removed under reduced pressure and the residue was purified by flash column chromatography on SiO2 using EtOAc/hexanes (0-30%) to afford the product (19) (397 mg) in 49% yield. 1H-NMR (CDCl3): δ 6.86-6.82 (m, 3 H), 4.80 (t, J=4.2-4.8 Hz, 1 H), 3.95-3.77 (m, 4 H), 3.878 (s, 3 H), 3.867 (s, 3 H), 2.24 (dt, J=3.9-4.2 Hz, J=12.9-13.2 Hz, 1 H), 2.11-2.02 (m, 1 H), 1.91 (dt, 1=3.9 Hz, J=12.6 Hz, 1 H), 1.72 (tt, J=3.9-4.2 Hz, J=12.6-13.2 Hz, 1 H), 1.37-1.24 (m, 1 H), 1.16 (d, J=6.6 Hz, 3 H), 0.80 (d, J=6.9 Hz, 3 H). LC-MS: 342.083 (MNa+).

Aufarbeitung

  1. additionwas added via syringe
  2. stirringThe mixture was stirred at −78° C. for five hours
  3. waitat room temperature for 17.5 hours
  4. customto quench
  5. customthe reaction
  6. customthe etheral solution was isolated
  7. extractionThe aqueous solution was extracted with ether (2×20 mL)
  8. washAfter washing with brine
  9. dry with materialdrying with sodium sulfate
  10. customthe solvent was removed under reduced pressure
  11. customthe residue was purified by flash column chromatography on SiO2

Quellen und Nachweise

ORD-Eintrag
ord-541f0821657a4495aa4d67af3763abcd
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09132200B2

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