Water → Ethyl 2-chloro-3-(2-nitrophenyl)-3-oxopropanoate

To a solution of ethyl 3-(2-nitrophenyl)-3-oxopropanoate (2.0 g, 8.4 mmol) in diethyl ether (50 mL), was added sulfuryl chloride (1.37 g, 10 mmol) at 0° C., and the mixture was stirred for 3 h at rt. To the reaction mixture were added water (200 mL) and EtOAc (100 mL), and the mixture was stirred for 30 min. The organic layer was washed with brine (10 mL) and dried over anhydrous magnesium sulfate. Insoluble materials were removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (1.7 g, 75%) as colorless oil.

1. stirringthe mixture was stirred for 30 min
2. washThe organic layer was washed with brine (10 mL)
3. dry with materialdried over anhydrous magnesium sulfate
4. customInsoluble materials were removed by filtration
5. concentrationthe filtrate was concentrated under reduced pressure

ORD-Eintrag

ord-1a7a59d42c174399ba42b10811930ef8

Quelldatensatz

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09139589B2