Sodium Acetate → 7-Methoxyflavone

HRID 2301344

Reaktionsgleichung

Reaktionsgleichung von HRID 2301344
O[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10](=[O:20])[CH2:11][C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13].C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH3:9][O:8][C:6]1[CH:5]=[C:4]2[C:3]([C:10](=[O:20])[CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:13]2)=[CH:2][CH:7]=1

Komponenten

4

Edukt 2

HCID 517045Sodium AcetateHCID 114145481-(2-Hydroxy-4-methoxyphenyl)-3-phenylpropane-1,3-dione

Produkt 1

HCID 4662687-MethoxyflavoneAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

240 mg (0.89 mmol) of 1-(2-hydroxy-4-methoxy-phenyl)-3-phenyl-propan-1,3-dione was dissolved in acetic acid, and 0.73 g (8.9 mmol) of sodium acetate was added thereto. The mixture was refluxed overnight. Acetic acid was removed by distillation under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: n-hexane/ethylacetate=5/1, v/v) to give the title compound in a yield of 70%.

Aufarbeitung

  1. temperatureThe mixture was refluxed overnight
  2. customAcetic acid was removed by distillation under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (eluent

Quellen und Nachweise

ORD-Eintrag
ord-59fd021b16774d859d824e784f15c118
Quelldatensatz
uspto-grants-2002_12
Patentnummer
US06500846B1

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