Water → 4-Ethylpyrrolo[1,2-a]pyrazine

Temperatur

-78 °C

1.0 g of pyrrolo[1,2-a]pyrazine prepared in Preparation Example 1 was dissolved in 10 ml of tetrahydrofuran and then cooled to -78° C. under nitrogen atmosphere. To this solution was added 1.2 equivalents of LDA solution; the resulting mixture was stirred for 30 minutes; and 1 ml of iodoethane was added to the mixture while maintaining the temperature of -78° C. The reaction mixture was stirred for 30 minutes, warmed to room temperature and then poured into water. The organic layer was isolated and then concentrated to dryness to obtain 0.3 g of title compound.

1. temperaturewhile maintaining the temperature of -78° C
2. stirringThe reaction mixture was stirred for 30 minutes
3. temperaturewarmed to room temperature
4. customThe organic layer was isolated
5. concentrationconcentrated to dryness

ORD-Eintrag

ord-eb306ae1bfc344cba9a9536013cb01a2

Quelldatensatz

uspto-grants-1997_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05593984