1-(4-Methoxyphenyl)-2-phenylethan-1-one → HCID 76529953, Verbindung

HRID 2378060Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2378060
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:5][CH:4]=1.Cl.[NH2:19][OH:20].C([O-])(=O)C.[Na+]>C(O)C.O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[N:19][OH:20])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:5][CH:4]=1

Komponenten

6

Edukt 3

HCID 2310931-(4-Methoxyphenyl)-2-phenylethan-1-oneHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

Produkt 1

HCID 76529953HCID 76529953, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution consisting of 1-(4-methoxy-phenyl)-2-phenyl-ethanone (commercially available, 1011 g, 4468 mmoles) in absolute ethanol (2 gallons) is added hydroxylamine hydrochloride (373 g, 5362 mmoles) and sodium acetate (440 g, 5362 mmoles.) The reaction mixture is stirred at room temperature for two days. The mixture is diluted with water (8 L) and the resultant mixture is stirred at room temperature for one hour. The mixture is subsequently filtered to give a solid, which is rinsed with water (3×4 L.) The product is dried to afford the synthetic intermediate 1-(4-methoxy-phenyl)-2-phenyl-ethanone oxime (948 g.)

Aufarbeitung

  1. filtrationThe mixture is subsequently filtered
  2. customto give a solid, which
  3. washis rinsed with water (3×4 L.) The product
  4. customis dried

Quellen und Nachweise

ORD-Eintrag
ord-745329d946ad4ca8a64e4ea90bb404b6
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07470715B2

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