2,2-Dimethyl-1,3-dioxane-4,6-dione → 6-Iodo-3-carboxy-coumarin

HRID 240036

Reaktionsgleichung

Reaktionsgleichung von HRID 240036
[I:1][C:2]1[CH:9]=[C:6]([CH:7]=O)[C:5]([OH:10])=[CH:4][CH:3]=1.CC1(C)O[C:17](=[O:18])[CH2:16][C:14](=[O:15])[O:13]1>O>[I:1][C:2]1[CH:9]=[C:6]2[C:5](=[CH:4][CH:3]=1)[O:10][C:17](=[O:18])[C:16]([C:14]([OH:15])=[O:13])=[CH:7]2

Komponenten

4

Edukt 2

HCID 162492,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 2526125-Iodosalicylaldehyde

Produkt 1

HCID 189964056-Iodo-3-carboxy-coumarinAusbeute 69 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

5-iodosalicylaldehyde (344.2 mg, 1.39 mmol) and Meldrum's acid (200 mg, 1.39 mmol) were combined in H2O (2 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 302.0 mg of 6-iodo-3-carboxy-coumarin in 69% yield.

Aufarbeitung

  1. temperatureAfter cooling to room temperature
  2. filtrationthe precipitate was filtered
  3. customdried at suction

Quellen und Nachweise

ORD-Eintrag
ord-fd89cebea6e1418f82f7f52836e62dc4
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642788B2

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