Water → 2-[3-ethoxycarbonylmethyl-6-fluoro-2(3H)-benzothiazolon-5-yl]4,5,6,7-tetrahydro-2H-isoindole-1,3-dione

HRID 2413865

Reaktionsgleichung

Reaktionsgleichung von HRID 2413865
[NH2:1][C:2]1[C:3]([F:18])=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:6]=2[CH:17]=1.[C:19]1(=O)[O:24][C:22](=[O:23])[C:21]2[CH2:25][CH2:26][CH2:27][CH2:28][C:20]1=2.O>C(O)(=O)C>[CH2:15]([O:14][C:12]([CH2:11][N:7]1[C:6]2[CH:17]=[C:2]([N:1]3[C:22](=[O:23])[C:21]4[CH2:25][CH2:26][CH2:27][CH2:28][C:20]=4[C:19]3=[O:24])[C:3]([F:18])=[CH:4][C:5]=2[S:9][C:8]1=[O:10])=[O:13])[CH3:16]

Komponenten

5

Edukt 3

HCID 962WaterHCID 124753,4,5,6-Tetrahydrophthalic anhydrideHCID 140142455-amino-3-ethoxycarbonylmethyl-6-fluoro-2(3H)-benzothiazolone

Produkt 1

HCID 140142462-[3-ethoxycarbonylmethyl-6-fluoro-2(3H)-benzothiazolon-5-yl]4,5,6,7-tetrahydro-2H-isoindole-1,3-dioneAusbeute 19,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

5-Amino-3-ethoxycarbonylmethyl-6-fluoro-2(3H)benzothiazolone (140 mg) and 3,4,5,6-tetrahydrophthalic anhydride (90 mg) were suspended in acetic acid (3 ml), and the resultant suspension was heated under reflux for 5 hours. After being allowed to cool, water was added thereto, and the resultant mixture was extracted with ethyl acetate. The extract was washed with water and sodium bicarbonate solution, dried and concentrated. The residue was purified by silica gel thin layer chromatography with a mixture of ethyl acetate and hexane (1:2) to give 2-[3-ethoxycarbonylmethyl-6-fluoro-2(3H)-benzothiazolon-5-yl]4,5,6,7-tetrahydro-2H-isoindole-1,3-dione (40 mg). m.p., 155.5°-156.5° C.

Aufarbeitung

  1. temperatureunder reflux for 5 hours
  2. temperatureto cool
  3. extractionthe resultant mixture was extracted with ethyl acetate
  4. washThe extract was washed with water and sodium bicarbonate solution
  5. customdried
  6. concentrationconcentrated
  7. customThe residue was purified by silica gel thin layer chromatography with a mixture of ethyl acetate and hexane (1:2)

Quellen und Nachweise

ORD-Eintrag
ord-48264d13f95e47fab5d8a3cd02fc2ddf
Quelldatensatz
uspto-grants-1988_01
Patentnummer
US04720297

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