Sodium Hydroxide → 1-(6-Chloropyrimidin-4-yl)azetidin-3-ol

HRID 242240Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 242240
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.Cl.[OH:10][CH:11]1[CH2:14][NH:13][CH2:12]1.[OH-].[Na+]>O>[Cl:8][C:6]1[N:7]=[CH:2][N:3]=[C:4]([N:13]2[CH2:14][CH:11]([OH:10])[CH2:12]2)[CH:5]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 775312,4-Dichloropyrimidine2×HCID 27592903-Hydroxyazetidine hydrochloride

Produkt 1

HCID 579250791-(6-Chloropyrimidin-4-yl)azetidin-3-olAusbeute 115,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

7.2 g (48.7 mmol) 2,4-dichloropyrimidine are initially introduced into 140 ml water. 5.3 g (48.7 mmol) 3-hydroxyazetidine hydrochloride and 48.7 ml 1 N sodium hydroxide solution are added and the mixture is heated at 90° C. for 72 h (the 2,4-dichloropyrimidine being detectably volatile and precipitating in crystalline form on the condenser). The solvent is removed in vacuo and the residue is dried to give 10.4 g of the crude product, which is reacted without further purification.

Aufarbeitung

  1. customprecipitating in crystalline form on the condenser)
  2. customThe solvent is removed in vacuo
  3. customthe residue is dried

Quellen und Nachweise

ORD-Eintrag
ord-ddae72d83b7742eca25dab5b5dbcefdf
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653111B2

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