Benzylamine → 6-benzylamino-3,4-dihydro-2H-isoquinolin-1-one

Temperatur

110 °C

In a small MW* sealed test tube was 6-bromo-3,4-dihydroisoquinolin-1(2H)-one (50 mg, 0.22 mmol), phenylmethanamine (24.16 µl, 0.22 mmol), palladium(II) acetate (2.483 mg, 0.01 mmol), Ethylenebis(diphenylphosphine) (8.81 mg, 0.02 mmol) and sodium methoxide (13.14 mg, 0.24 mmol) in toluene (2188 µl) combined to give a orange suspension. Heated reaction to 100°C overnight. Took LCMS - No reaction, only see unreacted SM. Discarded reaction.

ORD-Eintrag

ord-08bf18171af14ad9bb3d94faf7cd7b73

Quelldatensatz

750 AstraZeneca ELN dataset

Originallink

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