Carbon Dioxide → S-(alpha,beta-dicarboxyethyl)glutathione calcium

HRID 248802

Reaktionsgleichung

Reaktionsgleichung von HRID 248802
[C:1]([CH:4]([S:9][CH2:10][C@@H:11]([C:22]([NH:24][CH2:25][C:26]([OH:28])=[O:27])=[O:23])[NH:12][C:13](=[O:21])[CH2:14][CH2:15][C@@H:16]([C:18]([OH:20])=[O:19])[NH2:17])[CH2:5][C:6]([OH:8])=[O:7])([OH:3])=[O:2].C(=O)([O-])[O-].[Ca+2:33].C(=O)=O>O>[Ca:33].[C:1]([CH:4]([S:9][CH2:10][C@@H:11]([C:22]([NH:24][CH2:25][C:26]([OH:28])=[O:27])=[O:23])[NH:12][C:13](=[O:21])[CH2:14][CH2:15][C@@H:16]([C:18]([OH:20])=[O:19])[NH2:17])[CH2:5][C:6]([OH:8])=[O:7])([OH:3])=[O:2]

Komponenten

5

Edukt 3

HCID 280Carbon DioxideHCID 10112Calcium CarbonateHCID 9802383S-(1,2-Dicarboxyethyl)glutathione

Produkt 1

HCID 86746843S-(alpha,beta-dicarboxyethyl)glutathione calciumAusbeute 100,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

In 40 ml of water is dissolved 2 g of S-(α,β-dicarboxyethyl)glutathione followed by addition of 1 g of calcium carbonate. The mixture is stirred under warming. When the evolution of carbon dioxide gas has ceased, the excess of calcium carbonate is filtered off and the filtrate is concentrated under reduced pressure. To the concentrate is added ethanol and the resulting white crystals are collected by filtration and recrystallized from water-ethanol. Thus is obtained 2.2 g of the title compound as white powdery crystals.

Aufarbeitung

  1. temperatureunder warming
  2. filtrationthe excess of calcium carbonate is filtered off
  3. concentrationthe filtrate is concentrated under reduced pressure
  4. additionTo the concentrate is added ethanol
  5. filtrationthe resulting white crystals are collected by filtration
  6. customrecrystallized from water-ethanol

Quellen und Nachweise

ORD-Eintrag
ord-c2f5fdbeaf194800bb9fed483cfb3468
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05212159

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