Acetic Acid → 2,4'-Dibromopropiophenone

HRID 251766

Reaktionsgleichung

Reaktionsgleichung von HRID 251766
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.C(O)(=O)C.[Br:16]Br>O>[Br:16][CH:9]([CH3:10])[C:8]([C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1)=[O:11]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 24408Bromine2×HCID 66312p-Bromopropiophenone

Produkt 1

HCID 6039072,4'-DibromopropiophenoneAusbeute 64 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

Dissolving 5.0 g (23 mmol) of 4′-bromopropiophenon into 50 milliliter of acetic acid, and adding 3.7 g (23 mmol) of bromine while cooling with ice, stirred at the temperature of 10° C. for 3 hours. After the color of bromine disappeared, adding water and an extraction was carried out using dichloro-methane. Washing the organic layer with water, it was dried with the use of sodium sulfate. The solvent was removed by distillation and the resultant crystals were washed with hexane thereby obtaining 4.3 g of 2,4′-dibromopropiophenon (yield: 63%).

Aufarbeitung

  1. temperaturewhile cooling with ice
  2. extractionan extraction
  3. washWashing the organic layer with water, it
  4. dry with materialwas dried with the use of sodium sulfate
  5. customThe solvent was removed by distillation
  6. washthe resultant crystals were washed with hexane

Quellen und Nachweise

ORD-Eintrag
ord-d5e9e381744b4dad9487ebbcb5f6bf1d
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07867629B2

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