Water → 3-(2-Bromoacetyl)benzonitrile

HRID 251821

Reaktionsgleichung

Reaktionsgleichung von HRID 251821
[Br:1]Br.[C:3]([C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10])(=[O:5])[CH3:4].O>CCOCC>[Br:1][CH2:4][C:3]([C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10])=[O:5]

Komponenten

5

Edukt 3

HCID 962WaterHCID 24408BromineHCID 802223-Acetylbenzonitrile

Produkt 1

HCID 27358673-(2-Bromoacetyl)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Br2 (1 mmol) was dropwise added to a solution of 3-acetylbenzonitrile (1 mmol) in Et2O (15 ml) at 0° C., and then the mixture was stirred at r.t. for 4 h. Water was added, and the mixture was extracted with EtOAc. The organic layer was dried over Na2SO4, and was concentrated to give an oil, i.e., 3-(2-bromoacetyl)benzonitrile, which was directly used for the next step without purification.

Aufarbeitung

  1. extractionthe mixture was extracted with EtOAc
  2. dry with materialThe organic layer was dried over Na2SO4
  3. concentrationwas concentrated

Quellen und Nachweise

ORD-Eintrag
ord-bc195a55eb7041ccb0c4ce7b56ac6d09
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07868001B2

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