Pyridine → N-(3-(Oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide

HRID 259545

Reaktionsgleichung

Reaktionsgleichung von HRID 259545
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[O:9][C:10]3[C:11]([N:16]=2)=[N:12][CH:13]=[CH:14][CH:15]=3)[CH:5]=[CH:6][CH:7]=1.N1C=CC=CC=1.[C:23](OC(=O)C)(=[O:25])[CH3:24]>O>[C:23]([NH:1][C:2]1[CH:3]=[C:4]([C:8]2[O:9][C:10]3[C:11]([N:16]=2)=[N:12][CH:13]=[CH:14][CH:15]=3)[CH:5]=[CH:6][CH:7]=1)(=[O:25])[CH3:24]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 6110863-(Oxazolo[4,5-b]pyridin-2-yl)aniline

Produkt 1

HCID 2995970N-(3-(Oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 0.63 g. of 2-(3-aminophenyl)oxazolo[4,5-b]pyridine in 10 ml. of pyridine was treated with 0.35 ml. of acetic anhydride with stirring. After stirring over the weekend the mixture was diluted to 50 ml. with water. After stirring a short time and cooling, the precipitate was collected, washed with water and dried. Recrystallization from ethyl acetate gave 2-(3-acetamidophenyl)oxazolo[4,5-b]pyridine, m.p. 201.5°-202.5°.

Aufarbeitung

  1. additionwas diluted to 50 ml
  2. stirringAfter stirring a short time
  3. temperaturecooling
  4. customthe precipitate was collected
  5. washwashed with water
  6. customdried
  7. customRecrystallization from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-9562b43195984e0c811e2b8a33049552
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04038396

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