Acetic Acid → (4-chlorophenyl)(1H-imidazol-2-yl)phenylmethanol

HRID 261936

Reaktionsgleichung

Reaktionsgleichung von HRID 261936
C(OC[N:10]1[CH:14]=[CH:13][N:12]=[C:11]1[C:15]([C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[OH:16])C1C=CC=CC=1.C(O)(=O)C.Cl>O>[Cl:29][C:26]1[CH:25]=[CH:24][C:23]([C:15]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)([C:11]2[NH:12][CH:13]=[CH:14][N:10]=2)[OH:16])=[CH:28][CH:27]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 124339151-[(Benzyloxy)methyl]-alpha-(p-chlorophenyl)-alpha-phenylimidazole-2-methanol

Produkt 1

HCID 12433863(4-chlorophenyl)(1H-imidazol-2-yl)phenylmethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

About 17 g. (0.042 mol) of 1-[(benzyloxy)methyl]-α-(p-chlorophenyl)-α-phenylimidazole-2-methanol was boiled under reflux in a mixture of 85 ml. of glacial acetic acid, 8.5 ml. of water and 8.5 ml. of concentrated hydrochloric acid solution. Acetic acid was removed by evaporation and the base was liberated by addition of 2 N sodium hydroxide solution. It was crystallised from isopropyl alcohol. Melting point of the product was 162°-165° C.

Aufarbeitung

  1. temperatureunder reflux in a mixture of 85 ml
  2. customAcetic acid was removed by evaporation
  3. additionthe base was liberated by addition of 2 N sodium hydroxide solution
  4. customIt was crystallised from isopropyl alcohol
  5. customwas 162°-165° C.

Quellen und Nachweise

ORD-Eintrag
ord-cceeaee25d9846e69e81e02792f0e7c9
Quelldatensatz
uspto-grants-1979_05
Patentnummer
US04152441

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