StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- → 2-(2,2-dimethoxy-1-ethyl)-5-methoxy-1-tetralone N,N-dimethylhydrazone

HRID 264540
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 264540
[CH3:1][N:2]([CH3:16])[N:3]=[C:4]1[C:13]2[C:8](=[C:9]([O:14][CH3:15])[CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6][CH2:5]1.CN1C(=O)N(C)CCC1.C([Li])CCC.[CH3:31][O:32][CH:33]([O:36][CH3:37])[CH2:34]Br>C1COCC1.CCCCCC.O>[CH3:1][N:2]([CH3:16])[N:3]=[C:4]1[C:13]2[C:8](=[C:9]([O:14][CH3:15])[CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6][CH:5]1[CH2:34][CH:33]([O:36][CH3:37])[O:32][CH3:31]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

8

Edukt 4

HCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-HCID 816722-Bromo-1,1-dimethoxyethaneHCID 2909415-methoxy-1-tetralone N,N-dimethylhydrazoneHCID 178418339Butyllithium

Produkt 1

HCID 677142662-(2,2-dimethoxy-1-ethyl)-5-methoxy-1-tetralone N,N-dimethylhydrazoneAusbeute 37 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittelHCID 8058HexaneLösungsmittel

Versuchsvorschrift

3.12 g of 5-methoxy-1-tetralone N,N-dimethylhydrazone and 4.15 ml of DMPU were dissolved in 70 ml of absolute THF under argon and cooled to -75°. 10.7 ml of a 1.6M solution of n-butyllithium in hexane were added dropwise. The mixture was stirred at -75° for 1 hour and thereupon treated slowly with 2.0 ml of bromoacetaldehyde dimethyl acetal. The mixture was left to warm to room temperature and stirred for 26 hours. 20 ml of water were added at about 0° and the mixture was extracted three times with ethyl acetate. After drying over sodium sulfate, the mixture was filtered, evaporated and the residue was chromatographed on silica gel with toluene, then with toluene/ethyl acetate 9:1. 1.62 g (37%) of 2-(2,2-dimethoxy-1-ethyl)-5-methoxy-1-tetralone N,N-dimethylhydrazone were obtained as an oil.

Aufarbeitung

  1. temperaturecooled to -75°
  2. waitThe mixture was left
  3. stirringstirred for 26 hours
  4. extractionthe mixture was extracted three times with ethyl acetate
  5. dry with materialAfter drying over sodium sulfate
  6. filtrationthe mixture was filtered
  7. customevaporated
  8. customthe residue was chromatographed on silica gel with toluene

Quellen und Nachweise

ORD-Eintrag
ord-f0ae9af437a8485ebac27d545625552a
Quelldatensatz
uspto-grants-1997_07
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05646173

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion