Acetic Anhydride → 5-Bromo-2-methoxybenzonitrile

Temperatur

100 °C

A mixture of 5-Bromo-o-anisaldehyde (6.45 g), hydroxylamine hydrochloride (2.2 g), sodium acetate (4.1 g) and acedc acid (20 mL) was heated at 100° C. with stirring for 1 h. Acetic anhydride was added (20 mL) and the mixture was refluxed for 8 h. The reaction mixture was poured onto ice water and the mixture was made basic by the careful addition of 50% sodium hydroxide. The product was extracted with ether, the ether extracts were dried over magnesium sulfate and the solvent was removed in vacuo. The residue was crystallized from ether/hexane to afford 5-Bromo-2-methoxy-benzonitrile.

1. temperaturethe mixture was refluxed for 8 h
2. additionThe reaction mixture was poured onto ice water
3. extractionThe product was extracted with ether
4. dry with materialthe ether extracts were dried over magnesium sulfate
5. customthe solvent was removed in vacuo
6. customThe residue was crystallized from ether/hexane

ORD-Eintrag

ord-a2be2c360eaf4d348ce9e7cfd5c9bfe0

Quelldatensatz

uspto-grants-1997_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05646279