Benzaldehyde → 2-Aminopyridine

HRID 276158

Reaktionsgleichung

Reaktionsgleichung von HRID 276158
[CH:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(O)(=O)C1C=CC=CC=1.C=CCCCC.C1(C)C=CC=CC=1.[NH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][N:40]=1>>[C:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:8])[CH2:14][CH2:15][CH2:10][CH2:11][CH2:12][CH3:13].[NH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][N:40]=1

Komponenten

8

Edukt 6

HCID 240BenzaldehydeHCID 243Benzoic AcidHCID 1140TolueneHCID 6115AnilineHCID 104392-AminopyridineHCID 115971-Hexene

Produkt 2

HCID 104392-AminopyridineHCID 74282Heptanophenone

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

Under the same reaction procedure and conditions as in Example 1 (benzaldehyde 0.5 mmol, aniline 0.3 mmol, bezoic acid 0.03 mmol, 1-hexene 2.5 mmol, toluene 0.87 mmol), various 2-aminopyridine derivatives 0.1 mmol as shown in the following table 3, were added to each 500 ml pressure reactor. The mixture was stirred at normal temperature for 2-3 minutes and then combined with Rh(PPh3)3Cl 0.01 mmol. While the reactor was stopped with a stopper, the reactants were heated at 130° C. for 1 hour with stirring. After completion of the reaction, gas chromatography was conducted to determine the yields of heptanophenone, products from various aminopyridine derivatives. The results are presented in Table 3, below.

Aufarbeitung

  1. additionwere added to each 500 ml pressure reactor
  2. stirringwith stirring
  3. customAfter completion of the reaction, gas chromatography

Quellen und Nachweise

ORD-Eintrag
ord-fcceb4075c5c400f8b93bb53365b92fa
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06353139B1

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