Water → 4-Bromo-N,N-diisopropylbenzylamine

HRID 278572

Reaktionsgleichung

Reaktionsgleichung von HRID 278572
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH:10]([NH:13][CH:14]([CH3:16])[CH3:15])([CH3:12])[CH3:11].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:13]([CH:14]([CH3:16])[CH3:15])[CH:10]([CH3:12])[CH3:11])=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 7912DiisopropylamineHCID 11430Potassium CarbonateHCID 685274-Bromobenzyl bromide

Produkt 1

HCID 5987704-Bromo-N,N-diisopropylbenzylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 4-bromobenzylbromide (5.0 g), N,N-diisopropylamine (7.85 ml) and potassium carbonate (2.76 g) in dimethylformamide (50 ml) was stirred at 80° C. for 2 hours. To the mixture was added water, and the mixture was extracted with ether. The extract was washed with water, dried (MgSO4) and concentrated to give the title compound (5.0 g).

Aufarbeitung

  1. extractionthe mixture was extracted with ether
  2. washThe extract was washed with water
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-0947629a38f245a280dfe00ef647a3cd
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06359134B1

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