Bromine → 5-Bromo-4,6-dichloropyrimidin-2-amine

Temperatur

60 °C

To a stirred mixture of 4,6-dichloro-pyrimidin-2-yl-amine (2.46 g, 15.0 mmol) and sodium acetate (6.15 g, 75.0 mmol) in acetic acid (150 ml) was added bromine (3.24 g, 20.25 mmol) dropwise. The mixture was then stirred at 60° C. for 2 hours. Volatiles were evaporated under reduced pressure. The residue was stirred with water (500 ml) for 1 hour, filtered, and dried under reduced pressure to provide 2-amino-4,6-dichloro-5-bromo-pyrimidine (3.2 g, 88% yield) as a white solid.

1. customVolatiles were evaporated under reduced pressure
2. stirringThe residue was stirred with water (500 ml) for 1 hour
3. filtrationfiltered
4. customdried under reduced pressure

ORD-Eintrag

ord-16b556802db94a128af4492aaa101a92

Quelldatensatz

uspto-grants-2008_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07419984B2