Bromine → 5-Bromo-4,6-dichloropyrimidin-2-amine
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH2:9])[N:3]=1.C([O-])(=O)C.[Na+].[Br:15]Br>C(O)(=O)C>[NH2:9][C:4]1[N:5]=[C:6]([Cl:8])[C:7]([Br:15])=[C:2]([Cl:1])[N:3]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
To a stirred mixture of 4,6-dichloro-pyrimidin-2-yl-amine (2.46 g, 15.0 mmol) and sodium acetate (6.15 g, 75.0 mmol) in acetic acid (150 ml) was added bromine (3.24 g, 20.25 mmol) dropwise. The mixture was then stirred at 60° C. for 2 hours. Volatiles were evaporated under reduced pressure. The residue was stirred with water (500 ml) for 1 hour, filtered, and dried under reduced pressure to provide 2-amino-4,6-dichloro-5-bromo-pyrimidine (3.2 g, 88% yield) as a white solid.
Aufarbeitung
- customVolatiles were evaporated under reduced pressure
- stirringThe residue was stirred with water (500 ml) for 1 hour
- filtrationfiltered
- customdried under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-16b556802db94a128af4492aaa101a92
- Quelldatensatz
- uspto-grants-2008_09
- Patentnummer
- US07419984B2
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