Water → 4-(Hydroxyimino)-4-phenylbutanoic acid

HRID 32458

Reaktionsgleichung

Reaktionsgleichung von HRID 32458
O=[C:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].Cl.[NH2:15][OH:16].C([O-])(=O)C.[Na+].O>CCO>[N:15](=[C:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6])[OH:16]

Komponenten

6

Edukt 4

HCID 962WaterHCID 728713-Benzoylpropionic acidHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

Produkt 1

HCID 2319364-(Hydroxyimino)-4-phenylbutanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of 4-oxo-4-phenylbutyric acid (1.0 g, 5.3 mmol) in 50 mL of EtOH was added hydroxylamine hydrochloride (742 mg, 11 mmol) and sodium acetate (1.8 g, 21 mmol). The reaction flask was heated at 80° C. for 4 h and was then cooled to room temperature. Addition of water and filtration of the resultant precipitate afforded, after recrystallization (10:1 chloroform:hexane), 620 mg (60%) of the title compound.

Aufarbeitung

  1. temperaturewas then cooled to room temperature
  2. customafforded
  3. customafter recrystallization (10:1 chloroform:hexane), 620 mg (60%) of the title compound

Quellen und Nachweise

ORD-Eintrag
ord-68b393ec68034dac9628e5ad9b064591
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07427632B2

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