4-(2-(Benzyl(methyl)amino)-1-hydroxyethyl)benzene-1,2-diol → (+-)-Adrenaline

HRID 324713

Reaktionsgleichung

Reaktionsgleichung von HRID 324713
[CH2:1]([N:8]([CH2:10][CH:11]([C:13]1[CH:20]=[CH:19][C:17]([OH:18])=[C:15]([OH:16])[CH:14]=1)[OH:12])C)C1C=CC=CC=1.[H][H]>O.S(=O)(=O)(O)O.[Pd]>[CH3:1][NH:8][CH2:10][CH:11]([C:13]1[CH:20]=[CH:19][C:17]([OH:18])=[C:15]([OH:16])[CH:14]=1)[OH:12]

Komponenten

6

Edukt 2

HCID 220059034-(2-(Benzyl(methyl)amino)-1-hydroxyethyl)benzene-1,2-diolHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 838(+-)-Adrenaline

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 962WaterLösungsmittelHCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

Benzyladrenaline 2 is dissolved in about 10 ml of water and about 5 ml of 18% sulfuric acid (pH: about 5.5), about 50 mg of palladium-charcoal (10%) are added and the mixture is hydrogenated at about 60° C. under 2 bar of hydrogen pressure. It is then evaporated down to about half its volume, about 20 ml of methanol are added and the mixture is cooled. The crystalline product (adrenaline sulphate 3) is filtered off and dried.

Aufarbeitung

  1. customIt is then evaporated down to about half its volume, about 20 ml of methanol
  2. additionare added
  3. temperaturethe mixture is cooled
  4. filtrationThe crystalline product (adrenaline sulphate 3) is filtered off
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0d5d680909424c2b8d92acfc8a968ddf
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06218575B1

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