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Isophthaloyl chloride → 1-(3-Methylbenzoyl),3-(3-methylbenzoyl)benzene

HRID 333200
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 333200
Br[C:2]1[CH:3]=[C:4]([CH3:8])[CH:5]=[CH:6][CH:7]=1.[CH2:9]([Li])[CH2:10][CH2:11][CH3:12].[C:14](Cl)(=[O:24])[C:15]1[CH:23]=[CH:22][CH:21]=[C:17]([C:18](Cl)=[O:19])[CH:16]=1.O1C[CH2:29][CH2:28][CH2:27]1>>[CH3:12][C:11]1[CH:27]=[C:28]([CH:29]=[CH:9][CH:10]=1)[C:14]([C:15]1[CH:23]=[CH:22][CH:21]=[C:17]([C:18](=[O:19])[C:6]2[CH:7]=[CH:2][CH:3]=[C:4]([CH3:8])[CH:5]=2)[CH:16]=1)=[O:24]
KomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

5

Edukt 4

HCID 7451Isophthaloyl chlorideHCID 8028TetrahydrofuranHCID 115603-BromotolueneHCID 178418339Butyllithium

Produkt 1

HCID 541772461-(3-Methylbenzoyl),3-(3-methylbenzoyl)benzeneAusbeute 72 %

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

3-bromotoluene (6.684 g, 39.08 mmol) was dissolved in anhydrous tetrahydrofuran (30 mL) under an inert atmosphere of nitrogen. The solution was stirred for 5 min and cooled to −78° C. followed by the dropwise addition of n-butyllithium in hexanes (2.5M; 13.6 mL). After stirring for 3.5 h, the Weinreb amide of isophthaloyl dichloride was added dropwise and the solution was stirred for 1 h at −78° C. The reaction mixture was quenched with 1 M HCl (40 mL) and the products were extracted with dichloromethane (2×50 mL). The combined organic phases were washed with brine, dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. Purification using flash chromatography (silica gel, hexanes:ethyl acetate, gradient, 95:5 to 70:30) afforded 2.465 g, 9.77 mmol) 1-(3-methylbenzoyl),3-(3-methylbenzoyl)benzene 8 in a 72% yield.

Aufarbeitung

  1. stirringAfter stirring for 3.5 h
  2. stirringthe solution was stirred for 1 h at −78° C
  3. customThe reaction mixture was quenched with 1 M HCl (40 mL)
  4. extractionthe products were extracted with dichloromethane (2×50 mL)
  5. washThe combined organic phases were washed with brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. customthe solvent was removed under reduced pressure
  8. customPurification

Quellen und Nachweise

ORD-Eintrag
ord-7d242060510142afa59ea4798863c9ef
Quelldatensatz
uspto-grants-2014_11
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08877967B2

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