Bromine → 6-Bromo-2-fluoro-3-methoxybenzoic acid

HRID 335974

Reaktionsgleichung

Reaktionsgleichung von HRID 335974
[F:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:13]Br>C(O)(=O)C.O>[Br:13][C:7]1[C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[C:10]([O:11][CH3:12])=[CH:9][CH:8]=1

Komponenten

5

Edukt 2

HCID 24408BromineHCID 33906792-Fluoro-3-methoxybenzoic acid

Produkt 1

HCID 534387896-Bromo-2-fluoro-3-methoxybenzoic acidAusbeute 83,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To the suspension of 2-fluoro-3-methoxybenzoic acid (20 g, 118 mmol) in Acetic Acid (100 mL) and water (100 mL) at RT, bromine (12.05 mL, 235 mmol) was added dropwise. The reaction mixture was heated for 1 h at 60° C. The reaction was then cooled to RT and white precipitate was filtered. The solid was washed with excess water and dried to give 6-bromo-2-fluoro-3-methoxybenzoic acid (24.68 g, 99 mmol) as a white solid.

Aufarbeitung

  1. temperatureThe reaction was then cooled to RT
  2. filtrationwhite precipitate was filtered
  3. washThe solid was washed with excess water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5a2957c424af4dc5bd8f88bdb10436ce
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883782B2

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