Hydrochloric Acid → 3-Amino-2-chloro-5-fluoro-4-methylbenzoic acid

HRID 34578

Reaktionsgleichung

Reaktionsgleichung von HRID 34578
[Cl:1][C:2]1[C:10]([N+:11]([O-])=O)=[C:9]([CH3:14])[C:8]([F:15])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[O-]S(S([O-])=O)=O.[Na+].[Na+].Cl>COCCO.O>[NH2:11][C:10]1[C:2]([Cl:1])=[C:3]([CH:7]=[C:8]([F:15])[C:9]=1[CH3:14])[C:4]([OH:6])=[O:5]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 24489Sodium DithioniteHCID 136574392-Chloro-5-fluoro-4-methyl-3-nitro-benzoic acid

Produkt 1

HCID 136574403-Amino-2-chloro-5-fluoro-4-methylbenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittel2×HCID 80192-MethoxyethanolLösungsmittel

Versuchsvorschrift

18.5 g of 2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid and 51.5 g of Na2S2O4 are boiled in a mixture of 160 ml of glycol monomethyl ether and 160 g of water for 3 hours. 230 ml of 1/2-concentrated HCl are added to the still warm solution. The mixture is boiled up once more, cooled and poured into 560 ml of water. The solid which has precipitated is isolated and dried. Yield: 12.4 g, melting point: 182°-84°.

Aufarbeitung

  1. temperaturecooled
  2. customThe solid which has precipitated
  3. customis isolated
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-59d9ecf81f1c4d51bdbef875b42cf00b
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04762844

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