Water → 3-Benzyl-4-fluorobenzyl alcohol

HRID 34605Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34605
[CH2:1]([C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][C:15]=1[F:16])[CH:11]=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].O.C(OCC)C>CO>[CH2:1]([C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][C:15]=1[F:16])[CH2:11][OH:12])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 3283Diethyl EtherHCID 4311764Sodium borohydrideHCID 138542803-Benzyl-4-fluorobenzaldehyde

Produkt 1

HCID 138542813-Benzyl-4-fluorobenzyl alcoholAusbeute 79,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 3-benzyl-4-fluorobenzaldehyde (5 g) in methanol (75 cm3) was cooled to 0° C. Sodium borohydride (1.34 g) was added in portions, and the mixture stirred for 1 hour. The reaction mixure was then poured cautiously into a mixture of water and diethyl ether, and the organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulphate. Evaporation of the solvents under reduced pressure gave a pale yellow oil which was purified by distillation in a kugelrohr apparatus to give 3-benzyl-4-fluorobenzyl alcohol (4.0 g).

Aufarbeitung

  1. customthe organic layer was separated
  2. washwashed with water and brine
  3. dry with materialdried over anhydrous magnesium sulphate
  4. customEvaporation of the solvents under reduced pressure
  5. customgave a pale yellow oil which
  6. distillationwas purified by distillation in a kugelrohr apparatus

Quellen und Nachweise

ORD-Eintrag
ord-ea0c6157df9443dc8dbbec582469fa43
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04762835

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