Water → 2-Methoxybenzyl isothiocyanate

HRID 350634

Reaktionsgleichung

Reaktionsgleichung von HRID 350634
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][NH2:6].[C:11](Cl)(Cl)=[S:12].O>C(OCC)C>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][N:6]=[C:11]=[S:12]

Komponenten

5

Edukt 3

HCID 962WaterHCID 10040ThiophosgeneHCID 812922-Methoxybenzylamine

Produkt 1

HCID 1402562-Methoxybenzyl isothiocyanateAusbeute 99,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of 2-methoxybenzylamine (1.80 g) in diethylether (20 ml) was added dropwise under ice-cooling for 10 minutes thiophosgene (1.54 g). The mixture was stirred at room temperature for 1 hour. To the reaction solution was added water (30 ml), extracted with diethylether (60 ml), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give (2-methoxybenzyl)isothiocyanate (2.35 g, yield: 99%) as brown oil.

Aufarbeitung

  1. extractionextracted with diethylether (60 ml)
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ebf9e4bbd5ad47818e77d3b9f31b4e6b
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07183275B2

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